In Print
Photo by Graham Ramsay
From Focus:
When It Comes to Cell Cycle, Tail Wags Dog
The cell cycle is powered by the precisely ordered activation and deactivation
of dozens of regulatory proteins. The anaphase-promoting complex (APC) helps
drive the process by sequentially tagging proteins with ubiquitin, setting them
up for destruction in the proteasome. It is unclear, however, how the APC manages
to build these ubiquitin tails in the correct order. A recent paper by (left
to right) Michael Rape (pronounced RA-pa), Marc Kirschner, and Sashank Reddy
reports that proteins degraded earliest in the cycle are least likely to dissociate
from the APC once bound to it. Proteins degraded later dissociate readily. This
process ensures that the early proteins are the first to receive a full complement
of ubiquitin, which seals their fate in the proteasome.
Upcoming
Health Services
The Winter Wellness Health Fair
Feb. 9
11:30 a.m.–1:30 p.m.
Lab Works
A multimedia site featuring Harvard
Medical research.
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Spotlight
The Second Year Show: “A Funny Thing
Happened on the Way to the Fornix”
In her review, Tarayn Grizzard tells why to be afraid of Andy-bodies and—yikes!—four-color
pens. Photos by Steve Gilbert help tell the story.
Student Scene
Podcasting Comes to Med School
Curriculum
HMS has changed the iPod’s tune by making course lectures available on
this ubiquitous music machine.
StudenTalk
Personal takes on issues inside and
outside the classroom.
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