Oct. 4, 2004
In Print Photo by Leah Gourley From Focus: Chemical Genetics Identifies New Way of Disrupting Cell's Protein Recycling System Chemical genetics, the use of small inhibitors to disrupt biological pathways, may uncover interactions that traditional genetics misses. In the Oct. 1 Science, Randall King and colleagues describe a chemical genetic screen that uncovered ubistatins, small chemicals that interfere in a totally unexpected way with the cell's protein recycling system. Ubistatins, which bind to the interface between two ubiquitin molecules, make ubiquitin tags unrecognizable to the protein-recycling proteasome, thereby inhibiting protein degradation. Targeting the ubiquitin-ubiquitin interface could prove a novel approach to treating cancer.   Publications Online BBS Bulletin Focus HMI World HSTconnector MD-PhD Newsletter MedEd News Mentations On The Brain   Related Links InteliHealth Harvard Health Publications		Headlines Study Says Therapy Better than Pills in Treating Sleep-onset Insomnia [Select "In Research"] Study Finds that Blacks are Significantly Less Likely to Undergo Prostate Cancer Screening Rare Childhood Genetic Syndrome Identified Researchers Clarify Mechanisms for Beta-Cell Formation in Response to Insulin Resistance Upcoming Human Disease Seminar Series: "The Challenges of Tropical Diseases" Alex Matter, Director, Novartis Institute for Tropical Diseases Oct. 13 3:45 p.m.		Spotlight Photo by Steve Gilbert Martin Fills In Picture of Progress in State of the School Address In his seventh annual State of the School address, HMS dean Joseph Martin described some of the School's recent initiatives that are cutting new trails in science and biomedical education. Student Scene HMS Revamps Program in Medical Education Students will see a new organization in education programs at HMS, including two new divisions and the promotion of Nancy Oriol to Dean for Students. Lab Works A multimedia site featuring Harvard Medical research.

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